Home The Role of Gut Health in Testosterone Production

The Role of Gut Health in Testosterone Production

| May 9, 2025
| Marc Richmond M.D.

We usually think of testosterone as something that lives in the realm of muscles, masculinity, and the bedroom. But what if we told you your gut—yes, your digestive system—might be playing a major role in how much testosterone your body produces? It’s not the most obvious connection, but the relationship between gut health and hormone levels is real, and it’s more important than most men realize.

At Obsidian Men’s Health, we work with men every day who are struggling with symptoms of low testosterone, like fatigue, low libido, brain fog, weight gain, mood swings, and declining performance. While hormone therapy can be life-changing, we’re also interested in uncovering what’s happening upstream—what could be causing the dip in testosterone in the first place. For many men, the answer might lie in the gut.

Gut Health is More Than Just Digestion

When people talk about “gut health,” they’re usually referring to the state of your gastrointestinal tract, including your stomach, intestines, and the trillions of bacteria—collectively known as the gut microbiome—that live there. This ecosystem of bacteria is responsible for far more than just breaking down food. It helps regulate immune function, inflammation, mental health, and yes, hormone production.

Think of your gut as a control center for many of your body’s systems. When your gut is in good shape, everything from digestion to mood tends to function more smoothly. But when it’s off—due to poor diet, stress, medications, or infections—it can throw your whole body out of balance, including your hormonal system.

How Gut Health Influences Testosterone

The connection between your gut and your testosterone levels isn’t just theoretical; it’s backed by emerging research and growing clinical evidence. Here are a few key ways the gut can directly affect testosterone production:

1. Inflammation and Hormonal Disruption

An unhealthy gut often leads to chronic, low-grade inflammation throughout the body. This kind of inflammation interferes with the body’s ability to produce testosterone efficiently. When your gut lining is damaged (a condition sometimes referred to as “leaky gut”), harmful substances can pass into the bloodstream, triggering an immune response. That inflammation may reduce the function of the Leydig cells in the testes—the very cells responsible for producing testosterone.

In other words, if your gut is inflamed, your testosterone production may be impaired.

2. Gut Bacteria and Hormone Signaling

Your gut microbiome communicates with your endocrine system, which regulates hormones. Certain types of gut bacteria have been shown to promote the release of hormones like luteinizing hormone (LH), which stimulates testosterone production in the testes. When your gut flora is balanced and healthy, these hormonal signals can function properly. But when harmful bacteria outnumber the good, it can disrupt this delicate signaling network.

Researchers have even observed that mice raised in sterile, germ-free environments (with no gut bacteria at all) have significantly lower testosterone levels than mice with a normal microbiome. That’s not just a coincidence—it’s a clear sign that gut bacteria are helping to regulate hormone production at a fundamental level.

3. Nutrient Absorption and Testosterone Building Blocks

Your body needs certain nutrients to make testosterone, including zinc, magnesium, vitamin D, and healthy fats. But if your gut isn’t absorbing those nutrients properly, you may be running low on the raw materials needed for hormone synthesis.

Gut dysfunction—especially conditions like IBS, Crohn’s disease, or small intestinal bacterial overgrowth (SIBO)—can impair your ability to absorb these essential vitamins and minerals, even if your diet is technically on point. That means you could be eating well and still falling short hormonally if your gut isn’t pulling its weight.

4. Stress, the Gut-Brain Axis, and Testosterone

The gut is closely linked to your brain via the gut-brain axis, a communication network between your digestive tract and central nervous system. When you’re under chronic stress, your body produces more cortisol, the stress hormone. High levels of cortisol are known to suppress testosterone production.

Here’s where the gut comes in: poor gut health can increase your stress response and make it harder for your body to return to a calm, balanced state. If your gut is out of sync, your brain might be in a state of constant alert, keeping cortisol levels elevated—and testosterone levels low.

Signs Your Gut Might Be Hurting Your Hormones

Not sure if your gut is part of the problem? Here are some signs that your digestive system could be interfering with your hormonal health:

  • Frequent bloating, gas, or stomach discomfort
  • Irregular bowel movements (constipation or diarrhea)
  • Food sensitivities or unexplained fatigue after eating
  • Persistent fatigue, low sex drive, or mental fog
  • A diet heavy in processed foods, sugar, or alcohol

You don’t have to have a digestive disease to experience gut-related hormonal issues. Even mild, chronic imbalances can contribute to lower testosterone production over time.

How to Improve Gut Health and Support Testosterone, Naturally

The good news is that improving your gut health can also support healthy testosterone levels. Here are a few science-backed steps to get you started:

  • Clean up your diet. Prioritize whole, nutrient-dense foods—lean proteins, vegetables, fiber, and healthy fats—and minimize sugar, alcohol, and ultra-processed foods.
  • Add fermented foods and prebiotics. Foods like yogurt, kefir, sauerkraut, and kimchi introduce beneficial bacteria, while fiber-rich foods like onions, garlic, and bananas feed your good gut flora.
  • Consider a probiotic supplement. Not all probiotics are created equal, but a quality supplement can help restore microbial balance if your gut is out of whack.
  • Manage stress effectively. Practice stress-reducing activities like meditation, exercise, or simply getting more sleep—these help calm the gut-brain axis and lower cortisol.
  • Get tested. If you’re dealing with ongoing gut issues or symptoms of low testosterone, professional testing can uncover imbalances and guide targeted treatment.

Where Obsidian Comes In

At Obsidian Men’s Health, we don’t just look at your testosterone level in isolation. We take a holistic, personalized approach to your health—one that includes investigating root causes like gut dysfunction, nutrient deficiencies, and lifestyle habits that might be silently sabotaging your hormones. If your digestive health is undermining your performance and vitality, we can help you find a knowledgeable gastroenterologist to help. Request a consultation with the experts at Obsidian.

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